ATP-binding Cassette Transporter ABCB5 Gene is Expressed with Variability in Malignant Melanoma
نویسندگان
چکیده
منابع مشابه
ATP-binding cassette transporter ABCB5 gene is expressed with variability in malignant melanoma.
BACKGROUND Melanoma is a malignant neoplasm with high metastatic disease risk and elevated mortality. Incidence of melanoma varies according to geographic region and genetic BACKGROUND Epidemiological studies indicate that acral melanoma (AM) is among the most common melanomas in the Mexican population. While extensive studies have identified genes associated with melanoma, little is known ab...
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ABCB5, an ATP-binding cassette (ABC) transporter, is highly expressed in melanoma cells, and may contribute to the extreme resistance of melanomas to chemotherapy by efflux of anti-cancer drugs. Our goal was to determine whether we could functionally express human ABCB5 in the model yeast Saccharomyces cerevisiae, in order to demonstrate an efflux function for ABCB5 in the absence of background...
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ژورنال
عنوان ژورنال: Actas Dermo-Sifiliográficas (English Edition)
سال: 2010
ISSN: 1578-2190
DOI: 10.1016/s1578-2190(10)70645-4